.chemrytiq-page .chemrytiq-identityresolver-panel {
  margin-top: 1rem;
}

.chemrytiq-page .chemrytiq-identityresolver-workspace {
  display: none;
  gap: 1rem;
}

.chemrytiq-page .chemrytiq-identityresolver-workspace.is-active {
  display: grid;
}

.chemrytiq-page .chemrytiq-identityresolver-card {
  border: 1px solid #dbe6f2;
  border-radius: 0.9rem;
  background: #ffffff;
  box-shadow: 0 10px 26px rgba(15, 23, 42, 0.08);
  overflow: hidden;
}

.chemrytiq-page .chemrytiq-identityresolver-card__head {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 1rem;
  padding: 1rem 1.15rem;
  border-bottom: 1px solid #e6edf6;
  background: #f8fbff;
}

.chemrytiq-page .chemrytiq-identityresolver-kicker {
  margin: 0 0 0.25rem;
  color: #0f6dbb;
  font-size: 0.78rem;
  font-weight: 900;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.chemrytiq-page .chemrytiq-identityresolver-card__head h3 {
  margin: 0;
  color: #10263d;
  font-size: 1.15rem;
}

.chemrytiq-page .chemrytiq-identityresolver-badge,
.chemrytiq-page .chemrytiq-identityresolver-status {
  display: inline-flex;
  align-items: center;
  min-height: 1.7rem;
  padding: 0.2rem 0.55rem;
  border: 1px solid #d7e3ef;
  border-radius: 999px;
  background: #ffffff;
  color: #36546f;
  font-size: 0.76rem;
  font-weight: 850;
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-identityresolver-status.is-ok {
  border-color: #bbf7d0;
  background: #f0fdf4;
  color: #166534;
}

.chemrytiq-page .chemrytiq-identityresolver-status.is-warn {
  border-color: #fed7aa;
  background: #fff7ed;
  color: #9a3412;
}

.chemrytiq-page .chemrytiq-identityresolver-status.is-danger {
  border-color: #fecaca;
  background: #fef2f2;
  color: #b91c1c;
}

.chemrytiq-page .chemrytiq-identityresolver-status.is-source {
  border-color: #bfdbfe;
  background: #eff6ff;
  color: #1d4ed8;
}

.chemrytiq-page .chemrytiq-identityresolver-empty {
  display: grid;
  gap: 0.45rem;
  padding: 1rem 1.15rem;
  color: #5f7287;
  font-size: 0.92rem;
}

.chemrytiq-page #chemrytiqIdentityResolverIntro[hidden] {
  display: none !important;
}

.chemrytiq-page .chemrytiq-identityresolver-empty strong {
  color: #16324d;
  font-size: 1rem;
}

.chemrytiq-page .chemrytiq-identityresolver-empty ul {
  margin: 0.1rem 0 0;
  padding-left: 1.1rem;
}

.chemrytiq-page .chemrytiq-bioactivity-content {
  display: grid;
  gap: 1rem;
  padding: 1rem;
  background: #f6f9fc;
}

.chemrytiq-page .chemrytiq-bioactivity-metrics {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 0.75rem;
}

.chemrytiq-page .chemrytiq-bioactivity-metric {
  display: grid;
  gap: 0.25rem;
  min-height: 6.25rem;
  padding: 0.85rem 0.95rem;
  border: 1px solid #dce8f5;
  border-radius: 0.7rem;
  background: #ffffff;
}

.chemrytiq-page .chemrytiq-bioactivity-metric span {
  color: #55708a;
  font-size: 0.78rem;
  font-weight: 850;
  text-transform: uppercase;
}

.chemrytiq-page .chemrytiq-bioactivity-metric strong {
  color: #0f2742;
  font-size: 1.35rem;
  line-height: 1.15;
}

.chemrytiq-page .chemrytiq-bioactivity-metric small {
  color: #5e7388;
  font-size: 0.82rem;
  line-height: 1.35;
}

.chemrytiq-page .chemrytiq-bioactivity-grid {
  display: grid;
  grid-template-columns: minmax(0, 1.3fr) minmax(17rem, 0.7fr);
  gap: 0.8rem;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card {
  display: grid;
  gap: 0.65rem;
  padding: 0.9rem 1rem;
  border: 1px solid #dbeafe;
  border-left: 4px solid #2563eb;
  border-radius: 0.75rem;
  background: #eff6ff;
  color: #1e3a5f;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card.is-warn {
  border-color: #fed7aa;
  border-left-color: #f59e0b;
  background: #fff7ed;
  color: #7c2d12;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card.is-ok {
  border-color: #bbf7d0;
  border-left-color: #22c55e;
  background: #f0fdf4;
  color: #14532d;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-head {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 0.75rem;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-head div {
  display: grid;
  gap: 0.12rem;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-head span {
  color: inherit;
  font-size: 0.74rem;
  font-weight: 900;
  text-transform: uppercase;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-head strong {
  color: inherit;
  font-size: 1rem;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card p {
  margin: 0;
  color: inherit;
  line-height: 1.45;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card ul {
  display: grid;
  gap: 0.55rem;
  margin: 0;
  padding: 0;
  list-style: none;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card li {
  display: grid;
  gap: 0.2rem;
  padding: 0.58rem 0.65rem;
  border: 1px solid rgba(251, 191, 36, 0.45);
  border-radius: 0.55rem;
  background: rgba(255, 255, 255, 0.7);
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card li strong,
.chemrytiq-page .chemrytiq-bioactivity-conflict-card li span,
.chemrytiq-page .chemrytiq-bioactivity-conflict-card li em {
  color: inherit;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card li span,
.chemrytiq-page .chemrytiq-bioactivity-conflict-card li em {
  font-size: 0.84rem;
  line-height: 1.35;
}

.chemrytiq-page .chemrytiq-bioactivity-conflict-card li em {
  font-style: normal;
  font-weight: 800;
}

.chemrytiq-page .chemrytiq-identityresolver-mini-card {
  padding: 0.9rem 1rem;
  border: 1px solid #e2eaf3;
  border-radius: 0.75rem;
  background: #ffffff;
}

.chemrytiq-page .chemrytiq-identityresolver-mini-card h4 {
  margin: 0 0 0.6rem;
  color: #16324d;
  font-size: 0.98rem;
}

.chemrytiq-page .chemrytiq-identityresolver-mini-card p {
  margin: 0;
  color: #52677d;
  line-height: 1.45;
}

.chemrytiq-page .chemrytiq-bioactivity-target {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  gap: 0.35rem 0.75rem;
  align-items: start;
  padding: 0.65rem 0;
  border-top: 1px solid #edf2f7;
}

.chemrytiq-page .chemrytiq-bioactivity-target:first-of-type {
  border-top: none;
  padding-top: 0;
}

.chemrytiq-page .chemrytiq-bioactivity-target strong {
  display: block;
  min-width: 0;
  color: #10263d;
  line-height: 1.25;
  overflow-wrap: anywhere;
}

.chemrytiq-page .chemrytiq-bioactivity-target span {
  color: #607288;
  font-size: 0.84rem;
}

.chemrytiq-page .chemrytiq-bioactivity-target-meta {
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem;
  justify-content: flex-end;
  align-items: center;
  margin-top: 0;
}

.chemrytiq-page .chemrytiq-bioactivity-target-meta span {
  display: inline-flex;
  align-items: center;
  min-height: 1.45rem;
  padding: 0.12rem 0.48rem;
  border: 1px solid #dbe7f4;
  border-radius: 999px;
  background: #f5f9fe;
  color: #31516c;
  font-size: 0.78rem;
  font-weight: 850;
}


.chemrytiq-page .chemrytiq-bioactivity-insight-card {
  background: linear-gradient(180deg, #ffffff 0%, #f8fcff 100%);
}

.chemrytiq-page .chemrytiq-bioactivity-insight-card p {
  font-size: 1.05rem;
  color: #1f3d5a;
}

.chemrytiq-page .chemrytiq-bioactivity-hint-list {
  display: grid;
  gap: 0.35rem;
  margin: 0.65rem 0 0;
  padding-left: 1.05rem;
  color: #52677d;
  font-size: 0.88rem;
  line-height: 1.45;
}

.chemrytiq-page .chemrytiq-identityresolver-details {
  border: 1px solid #e2eaf3;
  border-radius: 0.75rem;
  background: #ffffff;
  overflow: hidden;
}

.chemrytiq-page .chemrytiq-identityresolver-details summary {
  display: flex;
  align-items: center;
  gap: 0.55rem;
  cursor: pointer;
  padding: 0.85rem 1rem;
  background: #f8fbff;
  color: #16324d;
  font-weight: 900;
  list-style: none;
}

.chemrytiq-page .chemrytiq-identityresolver-details summary::-webkit-details-marker {
  display: none;
}

.chemrytiq-page .chemrytiq-identityresolver-details summary::before {
  content: "›";
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 1.5rem;
  height: 1.5rem;
  flex: 0 0 auto;
  border: 1px solid #cfe0f2;
  border-radius: 999px;
  background: #eef6ff;
  color: #0f6dbb;
  font-size: 1.2rem;
  font-weight: 900;
  line-height: 1;
  transition: transform 0.16s ease, background 0.16s ease;
}

.chemrytiq-page .chemrytiq-identityresolver-details[open] summary::before {
  transform: rotate(90deg);
  background: #dff0ff;
}

.chemrytiq-page .chemrytiq-identityresolver-table-wrap {
  overflow-x: auto;
}

.chemrytiq-page .chemrytiq-identityresolver-table {
  width: 100%;
  min-width: 58rem;
  border-collapse: collapse;
  font-size: 0.82rem;
  background: #ffffff;
}

.chemrytiq-page .chemrytiq-identityresolver-table th,
.chemrytiq-page .chemrytiq-identityresolver-table td {
  padding: 0.65rem 0.75rem;
  border-top: 1px solid #edf2f7;
  text-align: left;
  vertical-align: top;
  overflow-wrap: anywhere;
}

.chemrytiq-page .chemrytiq-identityresolver-table th {
  color: #36546f;
  font-weight: 900;
}

.chemrytiq-page .chemrytiq-bioactivity-table td strong {
  display: block;
  color: #10263d;
  line-height: 1.3;
}

.chemrytiq-page .chemrytiq-bioactivity-target-name {
  display: flex;
  align-items: flex-start;
  gap: 0.45rem;
  min-width: 0;
}

.chemrytiq-page .chemrytiq-bioactivity-target-name strong {
  min-width: 0;
}

.chemrytiq-page .chemrytiq-bioactivity-structure-link {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 1.8rem;
  height: 1.45rem;
  flex: 0 0 auto;
  border: 1px solid #b7d7ff;
  border-radius: 0.35rem;
  background: #eff6ff;
  color: #145da0;
  cursor: pointer;
  font-size: 0.66rem;
  font-weight: 950;
  line-height: 1;
}

.chemrytiq-page .chemrytiq-bioactivity-structure-link:hover,
.chemrytiq-page .chemrytiq-bioactivity-structure-link:focus-visible {
  border-color: #3b82f6;
  background: #dbeafe;
  box-shadow: 0 0 0 3px rgba(59, 130, 246, 0.18);
}

.chemrytiq-page .chemrytiq-bioactivity-table td span {
  display: block;
  margin-top: 0.18rem;
  color: #64788d;
  font-size: 0.78rem;
  line-height: 1.3;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency {
  border-left: 3px solid transparent;
  font-variant-numeric: tabular-nums;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency strong,
.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency span {
  color: inherit;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency.is-hit {
  border-left-color: #15803d;
  background: #dcfce7;
  color: #14532d;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency.is-active {
  border-left-color: #65a30d;
  background: #ecfccb;
  color: #365314;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency.is-weak {
  border-left-color: #d97706;
  background: #fff7ed;
  color: #7c2d12;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency.is-inactive {
  border-left-color: #94a3b8;
  background: #f1f5f9;
  color: #475569;
}

.chemrytiq-page .chemrytiq-bioactivity-table td.chemrytiq-bioactivity-potency.is-unknown {
  border-left-color: #cbd5e1;
  background: #f8fafc;
  color: #64748b;
  cursor: help;
}

.chemrytiq-page .chemrytiq-bioactivity-table td .chemrytiq-bioactivity-conversion-note {
  display: inline-flex;
  width: fit-content;
  margin-top: 0.3rem;
  padding: 0.1rem 0.35rem;
  border: 1px solid currentColor;
  border-radius: 999px;
  font-size: 0.68rem;
  font-weight: 900;
  line-height: 1.2;
}

.chemrytiq-page .chemrytiq-bioactivity-table tbody tr:hover {
  background: #f8fbff;
}

.chemrytiq-page .chemrytiq-pdb-table {
  min-width: 78rem;
  table-layout: fixed;
}

.chemrytiq-page .chemrytiq-pdb-table th {
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(1),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(1) {
  width: 4.5rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(2),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(2) {
  width: 26rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(3),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(3) {
  width: 5.5rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(4),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(4) {
  width: 8.5rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(5),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(5) {
  width: 6.5rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(6),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(6) {
  width: 7rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(7),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(7) {
  width: 32rem;
}

.chemrytiq-page .chemrytiq-pdb-table th:nth-child(8),
.chemrytiq-page .chemrytiq-pdb-table td:nth-child(8) {
  width: 4.5rem;
}

.chemrytiq-page .chemrytiq-pdb-table td {
  white-space: normal;
}

.chemrytiq-page .chemrytiq-identityresolver-table tr.is-structure-focus {
  animation: chemrytiq-structure-focus 2.6s ease;
}

@keyframes chemrytiq-structure-focus {
  0%,
  100% {
    background: #ffffff;
  }

  18%,
  78% {
    background: #e0f2fe;
  }
}

.chemrytiq-page .chemrytiq-bioactivity-source-link {
  display: inline-flex;
  color: inherit;
  text-decoration: none;
}

.chemrytiq-page .chemrytiq-bioactivity-source-link:hover .chemrytiq-identityresolver-status,
.chemrytiq-page .chemrytiq-bioactivity-source-link:focus-visible .chemrytiq-identityresolver-status {
  border-color: #60a5fa;
  box-shadow: 0 0 0 3px rgba(96, 165, 250, 0.2);
}

.chemrytiq-page .chemrytiq-bioactivity-assay-groups {
  display: grid;
  gap: 0.6rem;
  padding: 0.75rem;
  background: #f8fbff;
}

.chemrytiq-page .chemrytiq-bioactivity-table-tools {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  justify-content: space-between;
  gap: 0.65rem;
  padding: 0.7rem 0.8rem;
  border: 1px solid #dce8f5;
  border-radius: 0.65rem;
  background: #ffffff;
  color: #52677d;
  font-size: 0.84rem;
  font-weight: 800;
}

.chemrytiq-page .chemrytiq-bioactivity-normalized-toggle {
  display: inline-flex;
  align-items: center;
  gap: 0.45rem;
  color: #16324d;
  cursor: pointer;
}

.chemrytiq-page .chemrytiq-bioactivity-normalized-toggle input {
  width: 1rem;
  height: 1rem;
  accent-color: #0f6dbb;
}

.chemrytiq-page .chemrytiq-bioactivity-quick-filters {
  display: grid;
  gap: 0.55rem;
  padding: 0.7rem 0.8rem;
  border: 1px solid #dce8f5;
  border-radius: 0.65rem;
  background: #ffffff;
}

.chemrytiq-page .chemrytiq-bioactivity-quick-filters > div {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 0.35rem;
}

.chemrytiq-page .chemrytiq-bioactivity-quick-filters > div > span {
  width: 4.8rem;
  flex: 0 0 auto;
  color: #52677d;
  font-size: 0.78rem;
  font-weight: 900;
  text-transform: uppercase;
}

.chemrytiq-page .chemrytiq-bioactivity-filter {
  min-height: 1.65rem;
  padding: 0.18rem 0.58rem;
  border: 1px solid #dbe7f4;
  border-radius: 999px;
  background: #f8fbff;
  color: #31516c;
  cursor: pointer;
  font-size: 0.78rem;
  font-weight: 850;
  line-height: 1.2;
}

.chemrytiq-page .chemrytiq-bioactivity-filter:hover,
.chemrytiq-page .chemrytiq-bioactivity-filter:focus-visible {
  border-color: #93c5fd;
  background: #eff6ff;
}

.chemrytiq-page .chemrytiq-bioactivity-filter.is-active {
  border-color: #0f6dbb;
  background: #e0f2fe;
  color: #0f3f70;
  box-shadow: inset 0 0 0 1px rgba(15, 109, 187, 0.14);
}

.chemrytiq-page .chemrytiq-bioactivity-assay-group {
  border: 1px solid #dce8f5;
  border-radius: 0.65rem;
  background: #ffffff;
  overflow: hidden;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-group summary {
  display: grid;
  grid-template-columns: 2rem auto auto auto auto auto auto 1fr;
  gap: 0.55rem;
  align-items: center;
  padding: 0.75rem 0.85rem;
  background: #ffffff;
  cursor: pointer;
  list-style: none;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-group summary::-webkit-details-marker {
  display: none;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-group summary::before {
  content: "›";
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 1.65rem;
  height: 1.65rem;
  border: 1px solid #cfe0f2;
  border-radius: 999px;
  background: #eef6ff;
  color: #0f6dbb;
  font-size: 1.35rem;
  font-weight: 900;
  line-height: 1;
  transition: transform 0.16s ease, background 0.16s ease;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-group[open] summary::before {
  transform: rotate(90deg);
  background: #dff0ff;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-group[open] summary {
  border-bottom: 1px solid #e8eef6;
  background: #fafdff;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-name {
  color: #10263d;
  font-weight: 900;
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-meta,
.chemrytiq-page .chemrytiq-bioactivity-assay-source {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 1.55rem;
  padding: 0.15rem 0.5rem;
  border: 1px solid #dbe7f4;
  border-radius: 999px;
  background: #f4f9ff;
  color: #395873;
  font-size: 0.76rem;
  font-weight: 850;
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-source {
  background: #eef6ff;
  color: #145da0;
}

/* Biochemical / Phenotypic paradigm badge in assay group header */
.chemrytiq-page .chemrytiq-bioactivity-assay-paradigm {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 1.35rem;
  padding: 0.1rem 0.45rem;
  border-radius: 999px;
  font-size: 0.72rem;
  font-weight: 900;
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-paradigm.is-biochemical {
  border: 1px solid #bbf7d0;
  background: #f0fdf4;
  color: #166534;
}

.chemrytiq-page .chemrytiq-bioactivity-assay-paradigm.is-phenotypic {
  border: 1px solid #fed7aa;
  background: #fff7ed;
  color: #9a3412;
}

/* Target functional-role group in Strongest Known Targets card */
.chemrytiq-page .chemrytiq-bioactivity-role-group {
  margin-top: 0.75rem;
}

.chemrytiq-page .chemrytiq-bioactivity-role-group:first-child {
  margin-top: 0;
}

.chemrytiq-page .chemrytiq-bioactivity-role-label {
  display: inline-flex;
  align-items: center;
  margin-bottom: 0.4rem;
  padding: 0.15rem 0.5rem;
  border-radius: 999px;
  font-size: 0.72rem;
  font-weight: 900;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  border: 1px solid #e2eaf3;
  background: #f4f9ff;
  color: #395873;
}

.chemrytiq-page .chemrytiq-bioactivity-role-label.is-primary {
  border-color: #bbf7d0;
  background: #f0fdf4;
  color: #166534;
}

.chemrytiq-page .chemrytiq-bioactivity-role-label.is-warn {
  border-color: #fed7aa;
  background: #fff7ed;
  color: #9a3412;
}

/* pIC50 chip in target meta and metric card */
.chemrytiq-page .chemrytiq-bioactivity-target-meta span.is-pact {
  background: #eff6ff;
  border-color: #bfdbfe;
  color: #1d4ed8;
  font-weight: 900;
}

.chemrytiq-page .chemrytiq-bioactivity-pact-chip {
  display: inline-flex;
  padding: 0.1rem 0.4rem;
  border: 1px solid #bfdbfe;
  border-radius: 999px;
  background: #eff6ff;
  color: #1d4ed8;
  font-size: 0.8rem;
  font-weight: 900;
}

/* "Biochemical assays only" note in card heading */
.chemrytiq-page .chemrytiq-bioactivity-paradigm-note {
  display: inline-flex;
  align-items: center;
  margin-left: 0.5rem;
  padding: 0.1rem 0.4rem;
  border: 1px solid #e2eaf3;
  border-radius: 999px;
  background: #f4f9ff;
  color: #52677d;
  font-size: 0.7rem;
  font-weight: 700;
  vertical-align: middle;
  text-transform: none;
  letter-spacing: 0;
}

.chemrytiq-page .chemrytiq-bioactivity-no-targets {
  margin: 0;
  color: #52677d;
  font-size: 0.9rem;
}

@media (max-width: 900px) {
  .chemrytiq-page .chemrytiq-bioactivity-metrics,
  .chemrytiq-page .chemrytiq-bioactivity-grid {
    grid-template-columns: 1fr;
  }

  .chemrytiq-page .chemrytiq-bioactivity-target {
    grid-template-columns: 1fr;
  }

  .chemrytiq-page .chemrytiq-bioactivity-target-meta {
    justify-content: flex-start;
  }

  .chemrytiq-page .chemrytiq-bioactivity-assay-group summary {
    grid-template-columns: 2rem 1fr;
    justify-items: start;
  }

  .chemrytiq-page .chemrytiq-pdb-qrdr-card-head {
    grid-template-columns: 1fr;
  }
}

/* ── QRDR Resistance-Determining Region styles ──────────────────────────────── */

.chemrytiq-page .chemrytiq-pdb-qrdr-badge {
  display: inline-flex;
  align-items: center;
  padding: 0.1rem 0.4rem;
  border: 1px solid #fca5a5;
  border-radius: 999px;
  background: #fef2f2;
  color: #991b1b;
  font-size: 0.68rem;
  font-weight: 900;
  letter-spacing: 0.04em;
  vertical-align: middle;
  cursor: default;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-details {
  margin-top: 0.75rem;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-details > summary {
  display: flex;
  align-items: center;
  gap: 0.55rem;
  flex-wrap: wrap;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-summary-badge {
  display: inline-flex;
  align-items: center;
  padding: 0.15rem 0.55rem;
  border: 1px solid #fca5a5;
  border-radius: 999px;
  background: #fef2f2;
  color: #991b1b;
  font-size: 0.72rem;
  font-weight: 900;
  letter-spacing: 0.04em;
  flex: 0 0 auto;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-summary-note {
  margin-left: auto;
  color: #7a8ca0;
  font-size: 0.75rem;
  font-weight: 700;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-body {
  display: grid;
  gap: 1rem;
  padding: 1rem;
  background: #fffbfb;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-card {
  display: grid;
  gap: 0.65rem;
  padding: 0.9rem 1rem;
  border: 1px solid #fecaca;
  border-left: 4px solid #f87171;
  border-radius: 0.65rem;
  background: #ffffff;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-card-head {
  display: grid;
  grid-template-columns: 1fr auto auto;
  gap: 0.65rem;
  align-items: center;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-card-head > div {
  display: flex;
  align-items: center;
  gap: 0.5rem;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-gene {
  display: inline-flex;
  padding: 0.1rem 0.45rem;
  border-radius: 0.3rem;
  background: #fee2e2;
  color: #7f1d1d;
  font-family: ui-monospace, SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
  font-size: 0.8rem;
  font-weight: 900;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-card-head strong {
  color: #1a2c3d;
  font-size: 0.95rem;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-region {
  padding: 0.15rem 0.5rem;
  border: 1px solid #e2eaf3;
  border-radius: 999px;
  background: #f4f9ff;
  color: #395873;
  font-size: 0.75rem;
  font-weight: 800;
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-link {
  padding: 0.2rem 0.55rem;
  border: 1px solid #bfdbfe;
  border-radius: 0.35rem;
  background: #eff6ff;
  color: #1d4ed8;
  font-size: 0.78rem;
  font-weight: 900;
  text-decoration: none;
  white-space: nowrap;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-link:hover {
  background: #dbeafe;
  border-color: #93c5fd;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-insight-text {
  margin: 0;
  color: #4a5568;
  font-size: 0.87rem;
  line-height: 1.5;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.82rem;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-table th,
.chemrytiq-page .chemrytiq-pdb-qrdr-table td {
  padding: 0.5rem 0.65rem;
  border-top: 1px solid #fee2e2;
  text-align: left;
  vertical-align: top;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-table th {
  background: #fff5f5;
  color: #7f1d1d;
  font-size: 0.75rem;
  font-weight: 900;
  text-transform: uppercase;
  letter-spacing: 0.04em;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-table td:first-child strong {
  color: #991b1b;
  font-family: ui-monospace, SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
}

.chemrytiq-page .chemrytiq-pdb-qrdr-code {
  font-family: ui-monospace, SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
  font-size: 0.82rem;
  color: #374151;
}